Role of p16 Immunohistochemistry in Cervical Intraepithelial Neoplasia
نویسندگان
چکیده
منابع مشابه
Evaluation of Ki67, p16 and CK17 Markers in Differentiating Cervical Intraepithelial Neoplasia and Benign Lesions
Background: Cervical intraepithelial neoplasia (CIN) is a premalignant lesion capable of progressing to cervical cancer. Despite the existing well-defined criteria, the histomorphologic diagnosis is subject to high rates of discordance among pathologists. The aim of this study was to evaluate Ki-67 (MIB-1), CK17 and p16 INK4a (p16) markers by immunohistochemical methods in differentiating CIN f...
متن کاملImpact of p16(INK4a) immunohistochemistry staining on interobserver agreement on the diagnosis of cervical intraepithelial neoplasia.
OBJECTIVES This study aimed to compare the interobserver Cohen κ on H&E staining and on H&E plus p16(INK4a) staining of all cervical biopsy specimens in a population-based screening program. METHODS All the colposcopy-guided biopsies generated by the routine screening of 23,258 women aged 25 to 64 years were stained with H&E and H&E plus p16. Biopsy specimens were reviewed by six external exp...
متن کاملevaluation of ki67, p16 and ck17 markers in differentiating cervical intraepithelial neoplasia and benign lesions
background: cervical intraepithelial neoplasia (cin) is a premalignant lesion capable of progressing to cervical cancer. despite the existing well-defined criteria, the histomorphologic diagnosis is subject to high rates of discordance among pathologists. the aim of this study was to evaluate ki-67 (mib-1), ck17 and p16 ink4a (p16) markers by immunohistochemical methods in differentiating cin f...
متن کاملAssessment of p16 and Ki67 Immunohistochemistry Expression in Squamous Intraepithelial Lesion with Cytohistomorphological Correlation
Background & Objective: Cervical cancer is the most common cancer in women worldwide with high mortality, necessitating quicker diagnostic methods. We wish to enhance th...
متن کاملCervical intraepithelial neoplasia.
The theoretical and practical reasons for replacing the terms "cervical dysplasia" and "cervical carcinoma in situ" by the single diagnostic entity of "cervical intraepithelial neoplasia" are reviewed and the advantages and drawbacks of this newer terminology discussed. The histological characteristics and cytological features of the various grades of cervical intraepithelial neoplasia are desc...
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ژورنال
عنوان ژورنال: JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
سال: 2020
ISSN: 2249-782X
DOI: 10.7860/jcdr/2020/41707.13549